Abstract
To evaluate immunomodulating activities of bioflavones, colony-stimulating factor
(CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols
were tested. These samples were suspended in saline and injected intraperitoneally
(i.p.) into mice at a dose of 1 mg 6 h before bleeding. All compounds carrying the glucosyl-rhamnose
moiety showed potent activity. Among them, hesperidin exhibited the strongest activity.
Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later.
The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.
